Researchers at the University of Pennsylvania School of Medicine speak opening grades of a slender enquiry reveal swear contained by rising erectile dysfunction (ED) in man who have shown minimal allergic reaction to Viagra. The study results be published in the March circulate of the "Journal of Sexual Medicine." Erectile dysfunction be recurrently a feeling of a more tyrannical vascular dilemma that enmesh abnormality in the inside covering of the vein. And often, endothelial dysfunction is an underlying problem all for ED - it can be one of the opening signs of atherosclerosis, a build-up of plaque and obstruction in the artery.
"It's already demanding that here is a sticking to involving erectile dysfunction and coronary virus. The stake factor are use illegally for both, and so, ED can be a engagement for coronary disease," explain outlook journalist Howard Herrmann, MD, Professor of Medicine and Director of the Interventional Cardiology and Cardiac Catheterization Laboratories at the Hospital of the University of Pennsylvania. "Normal erections are cause when nitric oxide is made, but near endothelial dysfunction, the article doesn't take den adequate of it, force the erectile dysfunction. Normally, Viagra rule out the dent of the unimportant nitric oxide particularly there, thus that there is enough of it for an erection to ensue." However, more or smaller amount 10-30 % of men are classified in leave of "Viagra non-responders" - in these men, Viagra accomplish not immensely give a appendage their erectile dysfunction. So in a small, doppelganger unsighted, randomized, placebo-controlled study at Penn, Herrmann look at a dozen patients with ED who had not respond okay to Viagra. He give them any a high-dose Lipitor or a placebo. He after rechallenged them with Viagra and command if the ED had better.
"There did give the impression of being to be several credit for those who received Lipitor versus the placebo," said Herrmann. "We theorize that if you could make the edothelium improved through the occupy of statins -- so that there is more nitric oxide accessible -- you would sort out the endothelial dysfunction and Viagra would drudgery recovered for the merciful." And there are other upcoming benefits additionally. Stan Schwartz, MD, Director of the Diabetes Disease Management program at Penn and co-author, move, "Patients with Diabetes, both Type 1 and Type 2, are plagued with complications of the diabetic state that involve endothelial dysfunction. This research tine us in a direction that say any remedy seminar that improve endothelial dysfunction may also be valuable to patients with diabetes." Additionally, Emile Mohler, MD, Director of Vascular Medicine at Penn and co-author, caution, "ED is a sign that cholesterol plaque may be presentation in the heart, decolletage or leg arteries. Men with ED should be evaluate for vascular disease." "These preliminary results show promise," add Herrmann. "They remain the presumption that erectile dysfunction may be one sign of a generalized vascular disarray characterized with endothelial dysfunction and that statin drugs may improve the endothelial dysfunction, even up and about to that occurrence altering the lipid profile. But the results are preliminary and warrant further carrying out tests in a larger clinical afflict," he cautions.
It should be noted that elapsed endothelial dysfunction, there are other sense Viagra may not work well for someone.
The results of this study be published in the March 2006 issue of the "Journal of Sexual Medicine." Members can access the log on-line at: a href"" target"_blank" The article is titled, "Can Atorvastatin Improve the Response to Sildenafil in Men with Erectile Dysfunction Not Initially Responsive to Sildenafil? Hypothesis and Pilot Trial Results." This study be support by an unrestricted medical center admit defeat from Pfizer.
About Penn's School of Medicine PENN Medicine is a $2.7 billion enterprise dyed-in-the-wool to the tied pursuit of medical environment, biomedical research, and superlative patient fastidiousness. PENN Medicine consists of the University of Pennsylvania School of Medicine (founded in 1765 as the nation's first medical school) and the University of Pennsylvania Health System.
Penn's School of Medicine is point #2 in the nation for getting of NIH research funds; and ranked #4 in the nation in U.S. News & World Report's maximum recent ranking of topmost research-oriented medical arts school. Supporting 1,400 fulltime faculty and 700 trainee, the School of Medicine is time-honoured communist for its soul in dependant education and habituation of the subsequent colleagues of physician-scientists and leaders of scholarly drug.
The University of Pennsylvania Health System list three hospital Hospital of the University of Pennsylvania, which is commonly ranked one of the nation's few "Honor Roll" hospitals by U.S. News & World Report; Pennsylvania Hospital, the nation's first treatment centre; and Penn Presbyterian Medical Center; a faculty run through mean; a primary-care provider gridiron; two multispecialty satellite services; and home care and hospice.
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