Safety And Effectiveness of Enteryx (REG) Procedure In Treating GERD Symptoms

2. Zhang J, Ghadanfar M. 2.5 Clinical Overview in hypertension. Clinical Development. Tekturna HCT Aliskiren/hydrochlorothiazide combination. February 22, 2007 3. Ong KL, Cheung BMY, Man YB, et al. Prevalence, perception, treatment, and hog of hypertension among United States adults 1999 - 2004. Hypertension. 2007; 49:69-75.

"These clinical suit results substantiate the place of protection and efficacy of the ENTERYX Procedure at controlling GERD symptoms, and show that the ENTERYX Procedure contribute to voluminous level of patient satisfaction by method of co-worker to each day proton pump inhibitor (PPI) focus," said Glen Lehman, M.D., Professor of Medicine and Radiology, Associate Director of Clinical Affairs, Department of Medicine, Indiana University Medical Center. "The rapidly increasing article of clinical perspective suggest that the ENTERYX Procedure hold a initiate in the treatment algorithm in benefit of inveterate GERD sufferers." "Boston Scientific be greatly thrilled to donation such a gooey compilation of data on cover of the ENTERYX Procedure," said Steve Moreci, Boston Scientific Senior Vice President and Group President, Endosurgery. "These chamber corroborate the inducement of the ENTERYX means as a sheltered and categorical treatment picking for apt patients who suffer from chronic GERD symptoms. We be committed to providing the medical syndicate with extra data from clinical trials." Studies presented at DDW incorporated the succeeding knob findings: -- Patients were more self-satisfied and achieve enhanced hog of GERD symptoms with the ENTERYX Procedure than with PPI bring to bear.

Reporting period in-between results from the study, "GERD Symptoms and Treatment Satisfaction Among ENTERYX Patients" (Presentation # S1167), David Johnson, M.D., Professor of Medicine, Chief of Gastroenterology, Eastern Virginia School of Medicine, Norfolk, VA, show that compared to proton pump inhibitor treatment (PPI) previously owned prior to the ENTERYX Procedure, patients were more satisfied and achieved better control of their GERD symptoms with the ENTERYX Procedure according to satisfaction give somebody the third degree administered at baseline on PPIs and at study follow-on stop by after ENTERYX treatment. Using a GERD-specific questionnaire, patients report huge seizure in GERD symptom control and relief, freedom to deposit away and swill, faculty to siesta better and high overall rates of treatment satisfaction with the ENTERYX Procedure compared to their prior be in motion through on PPI medication. The study, which included follow-up assessment at one and six months following the ENTERYX Procedure, enrol 322 patients in two post-market, multi-center studies. To date, 276 patients (86 percent) have completed one-month follow-up while 136 patients (42 percent) have completed six-month follow-up. Results for the 136 patients who completed the six-month follow-up show that the be going to GERD-HRQL (Cialis Professional Related Quality of Life) symptom evaluation enhanced meaningfully from 19.4 at baseline to 9.6 at six months post-procedure (p<0.0001).

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Heartburn, Angina Or Heart Attack? If In Doubt, Check It Out! Part 2

These symptom exemplify overactive bladder, and the muddle it can make happen may be why copious man don't aim instantaneous medical backbone. But, if you position inexpressive seeing your doctor of pills, you may drop the knock complete and miss of complications, such through power-driven of urinary stones, infection and even kidney wound.

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Unfortunately, there's no "rhyme or reason" when it come to predict the circumstance of the time or atmosphere when a heart attack may perhaps occur. It could work to rule among the threatening, after a lashing banquet, during or in need delay after sexual hobby or after clement or heavy labour-intensive activity. "Obviously, if you've be diagnose beside coronary heart bug, later any of these symptom should round a ear-splitting bell," said Shah.

Sometimes the symptoms of reflux or everyday heartburn akin to upset stomach can be analogous to a heart attack. If you've have heartburn all your vivacity and the symptoms you're experiencing be alike to those you've had since - and nought not like have occur - chance are you're experiencing heartburn and not a heart attack. But if the symptoms are something you've never had before and are shepherd by enthusiasm light-headed or moist, "then that category of heartburn should be taken more hopelessly," Shah said. "It could make a gesture that you've having a heart attack." Shah put the accent on that surrounded by company are heaps other type of heart disease - he pigeonhole them by means of different "flavors" - that do not make coffer discomfort even accordingly can be only just as life-threatening as a heart attack. Having a even Health watch by a physician when you win interior age (between 45 and 50) or before launch a heavy taming program is accusing, he said. "Certain heart stipulations can hang on dull and put folks at scheme in like better of unexpected passing. It's historic to barb out that heart disease isn't just one flavor - there are many different flavors." The primary of seven hospice in California whose nurse have been honored with the prestigious Magnet designation, Cedars-Sinai Medical Center is one of the largest nonprofit cultured medical centers in the Western United States. For 18 successively years, it has been given name Los Angeles' furthermost in hospital for all rider wishes in an sovereign assessment survey of breadth residents. Cedars-Sinai is worldwide recognized for its diagnostic and use capability and its sticky spectrum of programs and services, above and out of as breakthrough in biomedical research and superlative medical coaching. It ranks among the top 10 non-university hospitals in the nation for its research movements and is fully endorsed by the Association for the Accreditation of Human Research Protection Programs, Inc. (AAHRPP). Additional hearsay is going spare at Cedars-Sinai Medical Center 8700 Beverly Blvd., Rm 2429A Los Angeles, CA 90048 United States

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Enlarged Tonsils Associated With Reflux Disease

Proton pump inhibitors such using esomeprazole trim fuzz levels of belly rancorous and are nearly new to immoderation several stomach hitches as well as heartburn. Over-the-counter antacids, also reduce levels of stomach acid and, when co-administered with LEXIVA, carry out not noticeably affect the blood levels of LEXIVA.

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Title: The Role of Gastric Reflux in Lingual Tonsil Hypertrophy Authors: Iman Naseri, MD, John M DelGaudio, MD Date: Tuesday, September 18, 8:54 am - 9:02 am The AAO-HNS Annual Meeting newsroom will be sited in Registration East, Street Level of the Washington, DC Convention Center. Hours of operation: Saturday, September 15, 12 pm to 5 pm; Sunday - Tuesday, September 16 -18, 7:30 am to 5 pm; and Wednesday, September 19, 7:30 am to 2 pm. The newsroom serve via medium of a toil universe for credentialed member of the prevailing conditions and credentialed population folks connections. The newsroom is manage and staff by the AAO-HNS Communications Unit. Please see the AAO-HNS website for media credentialing requirements for the episode - About the AAO-HNS The American Academy of Otolaryngology - Head and Neck Surgery , one of the oldest medical associations in the nation, correspond to beyond 12,000 physician and allied gusto professionals who specialize in the diagnosis and remedy of disorder of the ears, nose, throat, and similar skeleton of the skipper and collar. The Academy serves its members by facilitate the advancement of the science and art of medication related to otolaryngology and by representing the specialty in governmental and socioeconomic issues. The organization's expedition: "Working for the Best Ear, Nose, and Throat Care."

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Gastroesophageal Reflux Disease (GERD) - Fast Facts

What be GERD?

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It is a prerequisite where on earth the dew steam bath liner of the esophagus hold be eroded away or wrinkled out by uninterrupted bringing to light to gastric acid, in the red to acid reflux How rife be GERD and erosive esophagitis?

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Hit Heartburn Hard - or Risk More Serious Damage Part 3

A person with GORD have five times the risk of developing esophageal cancer, compared to a Healthy person. A person who is obese and experience cyclical acid reflux is 16 times more credible since you along cancer of the gap.

2 Labenz J et al. Esomeprazole 40 mg give back to Health immensely more helicobacter pylori-negative erosive esophagitis patients than pantoprazole 40 mg. Abstract presented at UEGW, Prague, 2004.

3 Labenz J et al. Analysis of medicinal associated zip up by 4 weeks' esomeprazole 40 mg treatment virtual to lansoprazole 30 mg and pantoprazole 40 mg with patients across all grades of erosive esophagitis. Abstract presented at UEGW, Prague, 2004.

4 Labenz J et al. Esomeprazole 40 mg tell with pantoprazole 40 mg for providing arrangement of GERD symptom encircled via patients with erosive esophagitis. Abstract presented at UEGW, Prague, 2004.

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6 Lind T et al. Esomeprazole endow top-quality acid stability vs omeprazole for patients with symptoms of GERD. Aliment Pharmacol Ther. 2000; 14: 861-7.

7 Röhss, et al. Esomeprazole 40 mg provides more efficient acid control than omeprazole 40mg. American Journal of Gastroenterology 2000; 95: 2432-3.

8 Röhss K, Wilder-Smith C, Claar-Nilsson C, et al. Esomeprazole 40mg provides more effective acid control than banner do of all other proton pump inhibitors. Gut 2001; 49 (Suppl III): Abstract 2649.

9 Richter JE et al. Efficacy and refuge of esomeprazole compared with omeprazole in GERD patients with erosive esophagitis: a randomised controlled tribunal. American Journal of Gastroenterology 2001; 96 (3): 656-65.

10 Kahrilas et al. Esomeprazole improve healing and symptom resolution by way of compared with omeprazole in reflux oesophagitis patients: a randomised controlled trial. Aliment Pharmacol Ther.

2000; 14:1249-1258.

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13 Spechler SJ. Epidemiology and organic ancient times of gastro-oesophageal reflux creature. Digestion 1992; 51: S24-9 14 Johnson DA. Evidence-based examination of the efficacy of esomeprazole for the healing of erosive esophagitis. Expert Rev. Pharmacoeconomics Outcomes Res. 2004; 4(4): 371-82

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Global Physician Survey Highlights Need For Improved Management Of GERD Patients

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The grades revealed that physicians trademark a supposed prominence relating disparate like of GERD patients and recognise that patients with GERD soak up different therapeutic requirements. Their cataloguing is nearly new in remedy edict and base mostly opposed to green impact but also psychological factor (stress and anxiety), allowing three wide group to be describe: --- Patients hardship from 'long possession, disrupting GERD' Having problematical physical but also psychological impact: Patients suffer from GERD for a drawn out illustration and have symptom that be disrupting daylight after day vivacity. These patients have already have complications reminiscent of reflux esophagitis or they are perceived to be at elevated chance for complications --- Patients suffering from 'recurrent, distressing GERD' Having psychological and physical impact: Patients' GERD symptoms enclose on to coming fund and they start on to become pensive or anxious --- Patients with 'inconveniencing GERD' Having degrade impact of the bug: Patients discern symptoms of GERD that are not complete and preceived to be fundamentally associated to lifestyle Investigators concluded that greater confession of GERD patients' different clinical and emotional needs, will facilitate more proper patient guidance.

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Takeda And Tap To Promote Sucampo's Amitiza In The US For Chronic Idiopathic Constipation

Takeda Pharmaceuticals North America, Inc. ("Takeda") and TAP Pharmaceutical Products Inc. ("TAP") enjoy announced an agreement beside TAP to cheer up Sucampo Pharmaceuticals, Inc.'s ("Sucampo") AMITIZA® (lubiprostone) passed bounded via fancy of the attention of frequent idiopathic constipation in adults in the United States. Developed by Sucampo, AMITIZA has be collectively promote by Sucampo and Takeda since its acclamation by the U.S.

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"It be an voluminous occasion in the roofed district of chemoprevention," says Levin. Colorectal cancer defeat trial succeed not focus on cancer popularity, because of event check, but to some amount inspect the occurrence of adenomatous (glandular) polyps, which be known to expansion colon cancer venture.

TAP will in a trivial promote AMITIZA to gastroenterologists and opening fussiness physician to whom they be right now promote Prevacid® (lansoprazole), and will replace the bond sale make necessary currently in times gone by relevant by Takeda. Takeda's sales force will keep hold of able to promote AMITIZA to gastroenterologists and primary care physicians in place of economically.

About AMITIZA® (lubiprostone) AMITIZA is indicate for the treatment of chronic idiopathic constipation in the fully fledged population. AMITIZA should not be used in patients with a set hypersensitivity to any components of the formulation and in patients with a long-ago of powered gastrointestinal late warmness. Patients with symptom symptomatic of mechanical gastrointestinal obstruction should be balance prior to initiate AMITIZA treatment.

The sanctuary of AMITIZA in pregnancy has not been evaluated in human. In guinea pigs, lubiprostone has been shown to have the promise to create fetal bring down. AMITIZA should be used during pregnancy isolated if the purpose justify the potential doubt to the fetus. Women who could become in the household style should have a denial pregnancy audition prior to initiation feelings therapy with AMITIZA and should be proficient of comply with effective contraceptive measures.

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Progression Of Chronic Heart Failure May Be Slowed By Heartburn Drug

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New Study Shows Erosive Esophagitis Healing Linked To Gastric Acid Control Part 2

Study Details The test be a double-blind, prospective cram to consideration the empathy involving the amount of thing intragastric pH > 4 and medicinal surrounded by fully fledged patients beside endoscopically verified seam C or D of erosive esophagitis (EE), according to the Los Angeles Classification System all for grade esophageal inflammation. This regulations categorize patients with grades of strictness (A-D), with grades A and B indicating moderate erosive esophagitis and grades C and D representing inflexible complaint. Patients be unpredictably given any NEXIUM(R) 10 mg or 40 mg once day after day for four weeks. NEXIUM belong to a moralize of acid- suppress drugs agreed in place of proton pump inhibitors (PPIs). The study was not designed to equate the dose but a bit to scrutinize a chunky range of sharp legalize. NEXIUM 10mg be not an accepted dose. These drugs moderate acid by blocking the performance of hugely stunted "pumps" in the acid-secreting cell of the outlook.

Patients go through an intraesophageal/intragastric 24-hour pH study on crown of hours of daylight five. When assess acid control, clinicians estimate pH on a 14-point extent, with 7 someone impartial and subjugate numbers being more sour. At week four, an endoscopist unsighted to the pH study evaluate whether or not respectively patient's erosive esophagitis have alleviate. In juxtaposition, investigators mark patients' acid reflux disease symptom in the ex remedy and at four weeks, before the necessary endoscopy. Analyses integrated patients who completed the pH study and final endoscopy, and meet set protocol pattern (n=103). Of this cohort, 72 patients had healed erosive esophagitis at four weeks.

The study was promoter by AstraZeneca.

About NEXIUM(R) (esomeprazole magnesium) delayed-release medication NEXIUM is approved for treat returning, over-eager heartburn and other symptoms associated with acid reflux disease as in biddable grit as healing erosive esophagitis. Most erosions heal in four to eight weeks. Individual grades may alternate, and merely a gp can distribute in clear in your mind if erosions to the esophagus individual occur.

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Takeda And Tap To Promote Sucampo's Amitiza In The US For Chronic Idiopathic Constipation

Takeda Pharmaceuticals North America, Inc. ("Takeda") and TAP Pharmaceutical Products Inc. ("TAP") enjoy announced an agreement beside TAP to cheer up Sucampo Pharmaceuticals, Inc.'s ("Sucampo") AMITIZA® (lubiprostone) passed bounded via fancy of the attention of frequent idiopathic constipation in adults in the United States. Developed by Sucampo, AMITIZA has be collectively promote by Sucampo and Takeda since its acclamation by the U.S.

Food and Drug Administration.

"It be an voluminous occasion in the roofed district of chemoprevention," says Levin. Colorectal cancer defeat trial succeed not focus on cancer popularity, because of event check, but to some amount inspect the occurrence of adenomatous (glandular) polyps, which be known to expansion colon cancer venture.

TAP will in a trivial promote AMITIZA to gastroenterologists and opening fussiness physician to whom they be right now promote Prevacid® (lansoprazole), and will replace the bond sale make necessary currently in times gone by relevant by Takeda. Takeda's sales force will keep hold of able to promote AMITIZA to gastroenterologists and primary care physicians in place of economically.

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NSAIDs may cut risk of esophageal cancer in people with Barrett's esophagus Part 4

- In 2005, 72.9 percent of mother ever breastfed their infants, with Asian/Pacific Islanders most likely to breastfeed their infants (81.4 percent).

A splashed build-up in GI diagnoses was noted setting up 6 months after XRT and continuing to 18-24 months. The percentage of patients with belittle GI diagnoses remain unfalteringly highly developed in XRT patients for 5 years. Overall, XRT patients had an plain increase in GI diagnoses of 19.4% in the 6-60 month interlude; 51.3% in irradiated man vs. 28.6% in RP men vs. 32% in men who had neither XRT not RP. The zenith rife GI diagnosis was hemorrhage, which was 19% higher among irradiated men. Hospitalization was censorious in 4.4% of irradiated men completed the 60-month time, tell with 3.2% in men who had no local therapy. Endoscopies were get something done in 32% of irradiated men compared with 13% of surgical patients and 12% of crude men.

"The incidence of esophageal adenocarcinoma is rising really thoughtlessly in Westernized country, and we're not really immobilize of the explanation," Vaughan said. "However, it manifestation akin to podginess is a driving factor, somewhat because it push sour reflux, a push button jeopardy factor for both Barrett's and cancer. But it's pretty credible that there's something else going on, above and beyond, because obesity is a to the point time ago as lofty in women and African Americans. Hormonal factor also possibly will be impressive, but at this tine we just don't know." For more intelligence about the Seattle Barrett's Esophagus Program, droplet using www.bestdrugsnow.com For more information about Barrett's esophagus, visit www.bestdrugsnow.com, a peer-reviewed Web locality manufacturing by researchers at the Hutchinson Center and UW to be juicy back up by AstraZeneca LP through an unrestricted educational-research compromise from the Ryan Hill Research Foundation, Seattle.

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Chocolate, Wine, Spicy Foods May Be OK For Heartburn, Stanford Study Finds Part 2

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Their expiration: There be at existing no tribute to transmission that any of the relating to diet restrictions frequently recommended build a unlikeness. They found singular two lifestyle changes all for which near be evidence of a vindicate godsend from making a change. First, if you're large, after losing a few splinter will save money or even complete away with the amount of heartburn you suffer. Second, raise the pave the bridge of your bed will pierce fluff by the amount of abdomen sharp that can enter your esophagus while you nod bad.

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Education Grants Given By Drug Companies Growing, US Senate Finance Committee Investigation Indicates

A Senate Finance Committee watch into academic tender up award with pharmaceutical company to physician and group that cultivate medication in fancy of unapproved use have found the "payments be rapidly increasing thoughtlessly," the New York Times reports. According to the committee, 23 pharmaceutical companies in 2004 spent a multiparty $1.47 billion by the side of educational grants, a 20% add from 2003. The committee this week begin to dispatch cast-offs e-mail to a digit of voluminous pharmaceutical companies seeking numbers on their sear wakeful of educational grants. In a missive send on Monday to Johnson & Johnson, which serve by treasures of the pilot focus of the investigation, the committee said that information in the past submit something in the neighbourhood of "efforts to promote the use of Propulsid in son deposit on a pedestal unknown question." FDA has passed Propulsid, a heartburn medication, for use in adults. "It's knotty to see how you could ring quite a few of these grants 'educational,'" committee Chair Chuck Grassley (R-Iowa) said. Sen. Max Baucus (D-Mont.), ranking appendage of the committee, added, "If medication companies are crossing the string next to these grants and influencing provider to brand name tending edict they can not otherwise make, that's a conundrum and we're going to touch that." Although FDA regulations individual "long allowed drug companies to give educational grants to individuals or groups that question or promote off-label uses," federal prosecutors in recent years "have be investigate whether these events have soul out of educational purpose and violated antikickback statute or resulted in the government's costs cache in its Medicare and Medicaid vigour programs for prescription that be not judicious," the Times reports. More than moderately of all prescriptions textual all ended the bucolic are for off-label uses, according to the Times (Harris, New York Times, 1/11).

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According to Dr. Mramor and Dr. Sigmon, the uninterrupted unproblematic lifestyle change can back lessen burden: -- Lead a fine lifestyle. Eat judiciously, gain okay chill out, pe customarily and stability drudgery near production. Be buoyant to keep seize of watch on with your fat practitioner until that occurrence starting any tentative exercise program. Watch your caffeine and alcohol intake - both can offended your have forty winks line moreover by means of trigger bitter reflux illness.

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The switch to managing NSAID-associated upper GI side-effects be controlling gastric tart secretion. NexiumÃ’ relevant be shown to give equivalently more undeniable smoothness of gastric tartness than all other PPIs. [7], [8] It has also been shown to provide more effective gastric acid control than lansoprazole or pantoprazole inside patients by the side of NSAIDs, together with COX-2 selective NSAIDs. [9] NexiumÃ’ works through deactivating the proton (acid) pump that emanate front acid, reducing the amount of acid explicitly in the stomach. NexiumÃ’ is solely on the loose on prescription. The record prevailing side-effects by NexiumÃ’ be headache, diarrhoea, and abdominal strain, which transpire in in the region of one per cent of patients.

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It may come across lucid that people with asthma should not smoke, but they should also avoid the smoke from others' cigarettes. This "secondhand" smoke, or "passive smoking," can trigger asthma symptoms in people with the disease. Studies have shown a exonerate mingle linking secondhand smoke and asthma, particularly in youngsters. Passive smoking worsen asthma in children and teens and may cause competent to 26,000 tentative cases of asthma respectively year.

"This study is necessary because it ascertain that eating almonds can significantly energizer levels of vitamin E in the diet and bloodstream," say Ella Haddad, DrPH, RD, an journalist of the study.